BACK
Lab Technician Interview Questions
Lab technicians play a critical role in producing accurate, reliable data that informs everything from medical diagnoses to scientific breakthroughs. Whether working in healthcare, research, or industry, technicians are expected to follow strict procedures, maintain equipment, and spot issues before they become problems.
If you're preparing for a lab technician interview, expect questions that explore your technical skills, attention to detail, and ability to work under pressure. The examples below will help you prepare clear, thoughtful responses that show you're ready to contribute from day one.
Lab Technician Interview Questions
1. Which laboratory instruments are you proficient in operating, and how have you utilized them in past roles?
Interviewers want to assess your practical experience and technical scope, ensuring you are confident and competent with the equipment used in their facility. This question also helps them understand how your hands-on skills match the demands of the position.
Example Answer
"In my previous roles, I have become highly proficient in operating a variety of laboratory instruments, including centrifuges, spectrophotometers, PCR thermocyclers, automated analyzers, and balances. In my last position at a clinical diagnostics lab, I was responsible for running daily quality controls and using the PCR machine to test for infectious diseases. I also handled sample preparation using centrifugation and analyzed absorbance data using the spectrophotometer. My familiarity with these tools enabled me to not only run routine assays efficiently but also assist with troubleshooting when a machine was not working optimally, minimizing downtime and ensuring the workflow continued smoothly."
2. Can you explain the steps you take to calibrate and maintain lab equipment?
This question checks if you understand the importance of routine maintenance and calibration for equipment reliability. It also shows whether you are proactive in preventing issues that could compromise experimental results.
Example Answer
"I follow strict calibration protocols for every piece of lab equipment I use. This starts with reviewing the manufacturer's guidelines and the laboratory's standard operating procedures for the specific instrument. For example, with balances and pipettes, I use certified calibration weights and standards at the beginning of each day, document the results, and recalibrate if any values are outside acceptable ranges. Regular maintenance includes routine cleaning, inspecting moving parts for wear, and keeping detailed logs of service dates and any repairs. I also ensure that all calibrations are traceable by keeping meticulous records, which supports both data integrity and compliance during audits."
3. Describe your experience with specific laboratory techniques, such as PCR, ELISA, or spectrophotometry.
Here, the interviewer wants to gauge your depth and breadth of technical expertise. Sharing real-world applications proves you're capable of handling the core duties required for the role.
Example Answer
"I have extensive hands-on experience with PCR for amplifying DNA samples, ELISA for antibody detection, and spectrophotometry for measuring concentrations of analytes. In my most recent position, I routinely set up PCR reactions, optimized thermal cycling conditions, and interpreted gel electrophoresis results to confirm successful amplification. I also prepared samples for ELISA, managed standard curves, and analyzed absorbance readings for accurate quantification. Spectrophotometry was a key part of protein and nucleic acid quantification, where I performed wavelength scans and ensured proper calibration. This background has allowed me to work effectively in both research and clinical environments, always producing reliable data."
4. How do you ensure the accuracy and reliability of test results?
Accuracy and reliability are the foundation of laboratory work. This question is intended to see if you have effective strategies, habits, and checks in place to guarantee the integrity of your results.
Example Answer
"Ensuring accuracy and reliability starts with careful sample handling and adherence to standardized protocols. I always run positive and negative controls alongside test samples to verify assay performance. Double-checking calculations, calibrating equipment before use, and logging all data immediately help catch errors early. If there are discrepancies or unexpected results, I review the process, repeat the test if needed, and consult with colleagues to resolve any uncertainties. Documenting each step and following a clear quality assurance protocol ensures that results are dependable and reproducible, which is crucial for clinical decision-making and research validity."
5. What procedures do you follow to prevent cross-contamination in the lab?
This question tests your understanding of good laboratory practice, especially as cross-contamination can compromise results and patient safety. It also reveals your attention to detail and adherence to protocols.
Example Answer
"To prevent cross-contamination, I always use designated workspaces for specific tasks, wear new gloves when handling different samples, and thoroughly clean surfaces and equipment between uses. I utilize barrier pipette tips and sterile disposables where possible. Each sample is carefully labeled to avoid mix-ups, and I implement strict workflows that separate pre- and post-amplification areas when performing molecular assays. All these steps are combined with regular training for both myself and the team, ensuring that good laboratory practice is maintained at every stage."
6. Have you ever developed or modified a standard operating procedure (SOP)? If so, please elaborate.
Interviewers want to see if you take initiative to improve processes and whether you have experience formalizing best practices. This question highlights your leadership potential and ability to contribute to ongoing lab improvement.
Example Answer
"Yes, in my previous laboratory, I noticed that the DNA extraction SOP was outdated and resulting in inconsistent yields. I reviewed current literature, discussed possible improvements with colleagues, and conducted a series of pilot tests to compare reagents and incubation times. After gathering enough data, I wrote a revised SOP that streamlined steps and clarified ambiguous instructions. I also trained staff on the changes and incorporated feedback from their initial experiences. This improved consistency and reduced error rates, earning positive recognition from both my supervisor and my peers."
7. What is your approach to handling hazardous materials and ensuring safety compliance?
The safe handling of hazardous materials is critical in any lab. Interviewers ask this to make sure you are safety-conscious, understand regulations, and can be trusted to protect both people and data.
Example Answer
"My approach is to strictly adhere to all relevant safety protocols and ensure I am always up to date on safety training. When handling chemicals or biological hazards, I use the appropriate personal protective equipment, work in fume hoods or biosafety cabinets as needed, and follow protocols for labeling and storing hazardous materials. I also ensure all waste is disposed of properly in accordance with regulations, and I immediately report spills or exposures. Regular participation in safety drills and audits keeps my knowledge current and helps promote a culture of safety in the lab."
8. Can you discuss your familiarity with Good Laboratory Practice (GLP) standards?
GLP compliance is essential for traceability and credibility in scientific research. This question assesses your experience with documentation, protocol adherence, and overall quality control.
Example Answer
"I have worked in laboratories that strictly followed GLP guidelines, which include comprehensive documentation, clear SOPs, and meticulous record-keeping. My responsibilities included maintaining accurate logs for every experiment, storing raw data securely, and ensuring that any deviations from protocol were documented and investigated. I have been part of internal audits, during which I helped review our lab's compliance and suggested improvements for documentation practices. My commitment to GLP ensures that all work is traceable, reproducible, and defensible in audits or regulatory reviews."
9. Describe a time when you had to troubleshoot a malfunctioning piece of equipment.
Troubleshooting is a vital skill for minimizing downtime and maintaining lab productivity. This question shows your technical problem-solving abilities and resourcefulness.
Example Answer
"Once, during a critical run, the spectrophotometer began giving erratic readings. I checked the calibration status, inspected the lamp and cuvettes for defects, and cleaned all optical components. After consulting the instrument manual and running a diagnostic, I identified a loose cable connection inside the device. I secured the connection, recalibrated the instrument, and confirmed normal operation with standard solutions. This quick troubleshooting minimized downtime and ensured the accuracy of our results, which was crucial for meeting our project deadlines."
10. How do you stay updated with advancements in laboratory technology and methodologies?
The laboratory field evolves rapidly, so interviewers want to know if you're proactive in keeping your knowledge and skills current.
Example Answer
"I am committed to professional development and make it a habit to read scientific journals, attend webinars, and participate in relevant workshops. I am also an active member of online forums and professional associations where new technologies and best practices are discussed. When our lab acquires new equipment or adopts new techniques, I am often the first to volunteer for training and then help onboard the rest of the team, sharing what I have learned so everyone can benefit."
11. Can you provide an example of a time you improved a laboratory process or workflow?
Improvement and innovation are highly valued in modern labs. This question shows whether you notice inefficiencies and take initiative to address them.
Example Answer
"At my last job, I noticed that our sample preparation workflow for a particular assay was causing delays, especially during busy periods. I analyzed the process and identified that certain tasks could be batched and that better labeling reduced time spent tracking samples. I introduced a barcoding system and reorganized the prep area for smoother movement between stations. These changes reduced turnaround times by about 20 percent and were quickly adopted as the new standard operating procedure, benefiting both the team and the lab's output."
12. How do you approach learning a new laboratory technique or procedure?
Labs need technicians who can adapt to new methods and technologies. This question explores your learning process and willingness to keep growing.
Example Answer
"When learning something new, I begin by thoroughly reviewing any available protocols and relevant literature to understand the theory behind the technique. I watch demonstrations if possible and take detailed notes, then practice the procedure under supervision to build confidence. I am not afraid to ask questions, and I document any tips or common pitfalls I encounter for future reference. This methodical approach allows me to master new skills quickly while ensuring I can teach others if needed."
13. Describe a scenario where you had to make a quick decision without complete information.
Laboratories can be fast-paced and unpredictable. This question helps assess your judgment, responsibility, and ethical standards under pressure.
Example Answer
"Once, during a busy shift, a batch of patient samples arrived with some labels missing. The supervisor was unavailable, and I needed to act quickly to avoid delays. I checked our SOP and confirmed that unlabeled or ambiguously labeled samples had to be rejected to maintain data integrity. I logged the issue, notified the appropriate medical team, and ensured proper documentation. Although it was a difficult call, it prevented potential mix-ups and reinforced the importance of strict sample tracking for patient safety."
14. Have you ever had to validate a new method or instrument? What was your approach?
Validation is essential for ensuring new processes are accurate and reliable. This question evaluates your experience with method development, experimentation, and documentation.
Example Answer
"Yes, I was involved in validating a new ELISA kit. I ran parallel tests with our existing kit, analyzing sensitivity, specificity, and reproducibility across multiple sample types. I documented all results, created comparison charts, and worked closely with both the vendor and my supervisor to interpret the findings. After a thorough review, we adopted the new kit because it offered better reliability and cost-effectiveness, and I was responsible for training colleagues on its use."
15. What strategies do you employ to ensure data integrity and prevent errors?
Data integrity is a non-negotiable requirement in any lab. Interviewers want to see that you have checks in place to detect and prevent errors before they escalate.
Example Answer
"I rely on checklists, strict adherence to protocols, and double-entry of critical data to minimize errors. I always use electronic data systems when possible and validate entries against original records. In cases where discrepancies arise, I immediately flag them, investigate the root cause, and document the resolution process. Regular audits and peer reviews of results also help maintain a high standard of data integrity in my work."
16. How do you handle situations where you must work under pressure to meet tight deadlines?
The ability to deliver quality work even under time constraints is highly valued. This question tests your time management, prioritization, and ability to remain calm.
Example Answer
"I prioritize tasks based on urgency and complexity, breaking down large workloads into manageable steps. If multiple deadlines converge, I communicate clearly with team members and supervisors to delegate where possible and keep everyone informed about progress. I stay calm under pressure, focus on accuracy, and avoid shortcuts that could compromise results. My experience has taught me that clear organization and proactive communication are the best ways to meet tight deadlines without sacrificing quality."
17. How do you handle conflicts or disagreements within a team setting?
Interviewers want to know if you can resolve disputes constructively while maintaining positive working relationships.
Example Answer
"I believe open communication and mutual respect are key to resolving conflicts. When disagreements arise, I make sure everyone has a chance to voice their perspective. I listen carefully, seek common ground, and aim for solutions that prioritize the team's goals and safety. If a resolution isn't reached quickly, I involve a supervisor or mediator to help facilitate a fair outcome. By maintaining professionalism and empathy, I help foster a positive and productive team environment."
18. Can you discuss your experience with training or mentoring new laboratory staff?
Many labs rely on senior staff to onboard and mentor new team members. This question checks if you can teach, share best practices, and help build team competence.
Example Answer
"I have trained new hires in proper lab techniques, safety protocols, and use of key instruments. My approach involves demonstrating tasks step by step, explaining the reasons behind each procedure, and providing hands-on guidance until they are comfortable. I also encourage questions and check in regularly to offer feedback and support. Mentoring new staff is something I enjoy, as it helps ensure that everyone on the team maintains high standards and feels confident in their role."
The Smarter Way to Prepare
Experience a smarter way to prepare with our interview simulator.
19. What role do you typically assume in team projects, and why?
Interviewers ask this to understand your preferred work style and how you complement team dynamics.
Example Answer
"I naturally gravitate toward roles that involve organizing workflows and ensuring quality control. I am detail-oriented and enjoy creating systems that help the team work efficiently and effectively. However, I am also comfortable stepping back and supporting others when needed, whether by assisting with data analysis, documentation, or troubleshooting. My flexibility and commitment to team success make me a reliable and supportive team member."
20. How do you provide constructive feedback to peers or subordinates?
Potential employers want to know whether you can give feedback in a supportive way for continuous improvement and a positive team atmosphere.
Example Answer
"When giving feedback, I focus on specific behaviors or results rather than personal attributes. I always begin by acknowledging what was done well before addressing areas for improvement. I use concrete examples and suggest actionable steps, inviting discussion to understand any challenges they might be facing. My goal is to help others grow and succeed, so I make sure the feedback is clear, respectful, and delivered in a supportive manner."
21. Describe a situation where you collaborated with other departments or external partners.
Interviewers want to know that you can work across organizational boundaries to achieve results.
Example Answer
"I collaborated with the IT department during the implementation of a new laboratory information management system. My responsibility was to represent the lab's needs, communicate technical requirements, and help design user-friendly interfaces. I also coordinated training sessions and gathered feedback from lab staff. Working closely with another department taught me the importance of clear communication and adaptability, ultimately ensuring a smooth rollout that benefited the entire organization."
22. How do you adapt your communication style when interacting with diverse teams?
Labs are increasingly multicultural and multidisciplinary. This behavioral interview question shows your flexibility and awareness of different communication preferences.
Example Answer
"I adjust my communication based on the audience and their level of expertise. With technical peers, I use precise terminology and focus on details. When working with non-technical staff or team members from different backgrounds, I avoid jargon and use visual aids or analogies to clarify concepts. I also pay attention to cultural differences in communication styles, which helps me build trust and ensures everyone is on the same page."
23. How do you manage and organize laboratory records and documentation?
Proper documentation ensures traceability, regulatory compliance, and efficient operations. This question reveals your organizational skills and attention to compliance.
Example Answer
"I use both electronic and paper-based systems as required, keeping records meticulously organized by date, type, and project. I ensure that all data entries are complete, accurate, and easy to retrieve during audits. Regular reviews and updates to filing systems help maintain order and support quick access to information when needed, which is vital for both daily operations and compliance checks."
24. Describe your experience with laboratory information management systems (LIMS).
LIMS proficiency is becoming increasingly important in modern labs. Interviewers want to see if you can effectively use these systems to enhance lab productivity and accuracy.
Example Answer
"I have used several LIMS platforms to manage sample tracking, data entry, and report generation. I am proficient in entering test results, flagging abnormal findings, and training new users on the system. LIMS has improved our lab's efficiency and reduced manual errors, and I have been involved in customizing system workflows to better fit our lab's needs."
25. What methods do you use to track inventory and ensure adequate supplies?
Inventory management is critical for uninterrupted lab operations and budget control. This question shows your organizational skills and foresight.
Example Answer
"I conduct regular inventory checks, maintain detailed logs of stock levels, and set reorder points in our tracking system. For critical supplies, I keep buffer stock and monitor expiration dates to avoid waste. Good communication with vendors and the procurement team helps ensure we never run out of essential materials, which keeps lab operations running smoothly."
26. How do you schedule and prioritize routine maintenance and calibration of equipment?
Proactive maintenance prevents costly breakdowns and maintains data quality. Interviewers want to see your ability to plan and keep accurate maintenance records.
Example Answer
"I keep a detailed maintenance calendar, integrating manufacturer recommendations with our lab's usage schedules. I schedule calibration and maintenance during low-activity periods to minimize disruption. All maintenance activities are logged and reviewed during regular audits. This proactive approach helps avoid equipment failures and ensures we meet compliance standards."
A word of warning when using question lists.
Question lists offer a convenient way to start practicing for your interview. Unfortunately, they do little to recreate actual interview pressure. In a real interview you’ll never know what’s coming, and that’s what makes interviews so stressful.
Go beyond question lists using interview simulators.
With interview simulators, you can take realistic mock interviews on your own, from anywhere.
My Interview Practice offers a dynamic simulator that generates unique questions every time you practice, ensuring you're always prepared for the unexpected. Our AI-powered system can create tailored interviews for any job title or position. Simply upload your resume and a job description, and you'll receive custom-curated questions relevant to your specific role and industry. Each question is crafted based on real-world professional insights, providing an authentic interview experience. Practice as many times as you need to build your confidence and ace your next interview.
| List of Questions |
In-Person Mock Interview |
My Interview Practice Simulator |
|
|---|---|---|---|
| Questions Unknown Like Real Interviews | |||
| Curated Questions Chosen Just for You | |||
| No Research Required | |||
| Share Your Practice Interview | |||
| Do It Yourself | |||
| Go At Your Own Pace | |||
| Approachable |
The My Interview Practice simulator uses video to record your interview, so you feel pressure while practicing, and can see exactly how you came across after you’re done. You can even share your recorded responses with anyone to get valuable feedback.
Get the free training guide.
See the most common questions in every category assessed by employers and be ready for anything.
Get the Guide
Get Your Free Training Guide
Enter your email to receive your guide, and be ready for whatever questions come your way.
We hate spam and promise to keep your email safe.
